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AI That Predicts Cancer Spreading With 80% Accuracy

One of the most frightening things about cancer is not the tumor you can see but the possibility that it has already begun to quietly spread somewhere else in the body, and a new artificial intelligence tool developed at the University of Geneva can now predict that risk with nearly 80 percent accuracy. The tool, called MangroveGS, works by analyzing the activity of hundreds of genes in tumor cells and identifying patterns that reveal whether a cancer is likely to metastasize, which is the process of spreading to other parts of the body and the leading cause of cancer-related deaths. Researchers studying colon cancer discovered that metastatic potential is not determined by a single rogue cell acting alone but by how groups of cancer cells interact with each other, following something closer to a biological program than the random chaos scientists once assumed. The same gene patterns that predicted spreading in colon cancer also proved useful in predicting risk across stomach, lung and breast cancers, suggesting the tool may have broad applications well beyond any single disease.

The practical implications are significant and immediate. MangroveGS works directly with tumor samples already being collected in hospitals, analyzing their genetic material and generating a risk score shared securely with doctors and patients. For people whose cancers are deemed low risk, the tool could prevent unnecessary aggressive treatments and their painful side effects. For those at high risk, it could trigger more intensive monitoring and earlier intervention at the stage when treatment is most likely to succeed. The research team published their findings in Cell Reports, and scientists describe this kind of predictive precision as exactly the shift cancer care has been working toward, moving away from treating disease after it spreads toward identifying and acting on warning signs long before it does.

Source: https://www.sciencedaily.com/releases/2026/03/260321012709.htm

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